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Mouse Anti-p57 Kip2  antibody (bsm-34156M)
~~~促销代码KT202410~~~
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说明书: 50ul  100ul  
50ul/1180.00元
100ul/1980.00元
大包装/询价

产品编号 bsm-34156M
英文名称 Mouse Anti-p57 Kip2  antibody
中文名称 周期蛋白依赖激酶抑制因子1C单克隆抗体
别    名 Beckwith Wiedemann syndrome; BWCR; BWS; CDKI; CDKN 1C; CDKN1C; Cyclin dependent kinase inhibitor 1C; Cyclin dependent kinase inhibitor p57; KIP 2; KIP2; p57; p57 Kip2; p57 Kip 2; p57Kip2; WBS; IMAGE; CDN1C_HUMAN.  
抗体来源 Mouse
克隆类型 Monoclonal
克 隆 号 4E8
交叉反应 Mouse,Rat (predicted: Human)
产品应用 IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理论分子量 35kDa
细胞定位 细胞核 
性    状 Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human p57 Kip2 
亚    型 IgG2b, Kappa
纯化方法 affinity purified by Protein A
缓 冲 液 PBS (pH7.2), 0.03% Porcolin 300, containing stabilizing protein.
注意事项 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
产品介绍 This gene is imprinted, with preferential expression of the maternal allele. The encoded protein is a tight-binding, strong inhibitor of several G1 cyclin/Cdk complexes and a negative regulator of cell proliferation. Mutations in this gene are implicated in sporadic cancers and Beckwith-Wiedemann syndorome, suggesting that this gene is a tumor suppressor candidate. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2010].

Function:
Potent tight-binding inhibitor of several G1 cyclin/CDK complexes (cyclin E-CDK2, cyclin D2-CDK4, and cyclin A-CDK2) and, to lesser extent, of the mitotic cyclin B-CDC2. Negative regulator of cell proliferation. May play a role in maintenance of the non-proliferative state throughout life.

Subunit:
Interacts with PCNA.

Subcellular Location:
Nucleus.

Tissue Specificity:
Expressed in the heart, brain, lung, skeletal muscle, kidney, pancreas and testis. Expressed in the eye. High levels are seen in the placenta while low levels are seen in the liver.

DISEASE:
Defects in CDKN1C are a cause of Beckwith-Wiedemann syndrome (BWS) [MIM:130650]. BWS is a genetically heterogeneous disorder characterized by anterior abdominal wall defects including exomphalos (omphalocele), pre- and postnatal overgrowth, and macroglossia. Additional less frequent complications include specific developmental defects and a predisposition to embryonal tumors. Defects in CDKN1C are the cause of intrauterine growth retardation, metaphyseal dysplasia, adrenal hypoplasia congenita, and genital anomalies (IMAGE) [MIM:614732]. A rare condition characterized by intrauterine growth restriction, metaphyseal dysplasia, congenital adrenal hypoplasia, and genital anomalies. Patients with this condition may present shortly after birth with severe adrenal insufficiency, which can be life-threatening if not recognized early and commenced on steroid replacement therapy. Other reported features in this condition include, hypercalciuria and/or hypercalcemia, craniosynostosis, cleft palate, and scoliosis. Note=Defects in CDKN1C are involved in tumor formation.

Similarity:
Belongs to the CDI family.

SWISS:
P49918

Gene ID:
1028

Database links:

Entrez Gene: 1028 Human

Entrez Gene: 12577 Mouse

Entrez Gene: 246060 Rat

Omim: 600856 Human

SwissProt: P49918 Human

SwissProt: P49919 Mouse

SwissProt: E9PTV7 Rat

SwissProt: Q69DC0 Rat

Unigene: 106070 Human

Unigene: 168789 Mouse

Unigene: 162507 Rat



p57 Kip-2调控周期蛋白依赖蛋白激酶、G1 期, 是细胞周期蛋白依赖性激酶(CDK)的抑制蛋白。它通过调控细胞周期进程,参与肿瘤细胞的增殖、分化与凋亡。在多种肿瘤中均发现p57,kip2表达异常,在某些肿瘤中是一种独立的预后因素,与肿瘤的发生、发展及预后有着密切关系。
产品图片
Paraformaldehyde-fixed, paraffin embedded (rat placenta); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Incubation with (p57 Kip2 ) Monoclonal Antibody, Unconjugated (bsm-34156M) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Mouse)(sp-0024) instructionsand DAB staining.
Paraformaldehyde-fixed, paraffin embedded (Mouse placenta); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Incubation with (p57 Kip2 ) Monoclonal Antibody, Unconjugated (bsm-34156M) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Mouse)(sp-0024) instructionsand DAB staining.
Paraformaldehyde-fixed, paraffin embedded (mouse kidney); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Incubation with (p57 Kip2 ) Monoclonal Antibody, Unconjugated (bsm-34156M) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Mouse)(sp-0024) instructionsand DAB staining.
Paraformaldehyde-fixed, paraffin embedded (rat kidney); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Incubation with (p57 Kip2 ) Monoclonal Antibody, Unconjugated (bsm-34156M) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Mouse)(sp-0024) instructionsand DAB staining.
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