| 产品编号 | bs-2548R |
| 英文名称 | Rabbit Anti-CXCL4 antibody |
| 中文名称 | 血小板因子4抗体 |
| 别 名 | C-X-C motif chemokine 4; Chemokine (C X C motif) ligand 4; Chemokine (CXC motif) ligand 4; CXCL 4; CXCL4; Iroplact; MGC138298; Oncostatin A; Oncostatin-A; OncostatinA; PF 4; PF-4; PF4; Platelet factor 4; PLF4_HUMAN; SCYB 4; SCYB4; short form; Small inducible cytokine subfamily member 4. |
 |
Specific References (1) | bs-2548R has been referenced in 1 publications.
[IF=6.81] Hwaiz et al. Platelet secretion of CXCL4 is Rac1-dependent and regulates neutrophil infiltration and tissue damage in septic lung damage. (2015) Br.J.Pharmaco. 172:5347-59 IF ; Mouse.
|
| 研究领域 | 细胞生物 免疫学 生长因子和激素 趋化因子 血管内皮细胞 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | (predicted: Human,Mouse,Rat,Rabbit,Cow) |
| 产品应用 | WB=1:500-2000,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理论分子量 | 11kDa |
| 细胞定位 | 分泌型蛋白 |
| 性 状 | Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human CXCL4: 32-101/101 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 缓 冲 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 产品介绍 |
Chemokines are a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of 7 transmembrane, G protein coupled receptors. Chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. Chemokines are divided into 2 major subfamilies, CXC and CC, based on the arrangement of the first 2 of the 4 conserved cysteine residues; the 2 cysteines are separated by a single amino acid in CXC chemokines and are adjacent in CC chemokines. CXC chemokines are further subdivided into ELR and non ELR types based on the presence or absence of a glu leu arg sequence adjacent and N terminal to the CXC motif. Function: Released during platelet aggregation. Neutralizes the anticoagulant effect of heparin because it binds more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. Chemotactic for neutrophils and monocytes. Inhibits endothelial cell proliferation, the short form is a more potent inhibitor than the longer form. Subunit: Homotetramer. Subcellular Location: Secreted. Similarity: Belongs to the intercrine alpha (chemokine CxC) family. SWISS: P02776 Gene ID: 5196 Database links: Entrez Gene: 5196 Human Omim: 173460 Human SwissProt: P02776 Human Unigene: 81564 Human Unigene: 6800 Rat |
| 1、抗体溶解方法 | |
| 2、抗体修复方式 | |
| 3、常用试剂的配制 | |
| 4、免疫组化操作步骤 | |
| 5、免疫组化问题解答 | |
| 6、Western Blotting 操作步骤 | |
| 7、Western Blotting 问题解答 | |
| 8、关于肽链的设计 | |
| 9、多肽的溶解与保存 | |
| 10、酶标抗体效价测定程序 | |
